NR5A2 and colitis: Additionally, haploinsufficiency of LRH-1 renders mice more susceptible to experimentally induced colitis as demonstrated by increased necrotic regions and higher level of neutrophilic infiltration in the colon of LRH-1+/− mice treated with 2,4,6-trinitrobenzene sulfonic acid (TNBS) or DSS, compared with control littermates.