AKT1 and cancer: Although the PI3K product PI(3,4,5)P3 is well known to be a potent activator of cancer cell survival by promoting AKT activation, PI(3,4)P2 can also bind to the PH domain of AKT, and in fact does so in a manner that leads to more potent AKT activation through phosphorylation of AKT on Ser473 [4,60].