Therefore, since NEMO deficiency may lead to an overall manifestation of immune deficiency through poor response to bacterial and fungal infections from NK, B and T-cells, as well as neutrophils, macrophages and dendritic cells, the bacterial infections from Gram-negative anaerobic bacteria, which are implicated in the periodontal diseases, are also likely. The gene discussed is IKBKG; the disease is Immunodeficiency.