The mutations in TERT promoter (17%), TP53 (3%), and genes encoding three functional groups (HMTs, SWI/SNF chromatin remodeling complex, and the PI3K/AKT/mTOR pathway) ranged between that of PTCs from TCGA and PDTCs and ATCs from the MSKCC group. The gene discussed is AKT1; the disease is Ehlers-Danlos syndrome, musculocontractural type.