PBRM1 and Ehlers-Danlos syndrome, musculocontractural type: Genes encoding SWI/SNF chromatin remodeling complex were altered in 14% of samples, 6% in ARID1B, 6% in ARID2, and 3% in ATRX. No mutation was noted in ARID5B, SMARCB1, and PBRM1. The prevalence of mutations in HMTs (11%) and SWI/SNF chromatin remodeling complex (14%) in aggressive variants of PTC ranged between that of PDTCs (7% and 24%) and ATCs (6% and 36%) from MSKCC data (Figure 3A–D).