Mutations of genes encoding the members of the PI3K/AKT/mTOR pathway were found in 11% of samples: 3% in AKT1, 3% in AKT3, and 6% in ERRB3. The alteration of all functional groups was 34% in aggressive variants of PTCs, 20% in TCGA, and 61% in ATCs from MSKCC data (Figure 3). This evidence concerns the gene MTOR and Ehlers-Danlos syndrome, musculocontractural type.