Furthermore, the prevalence of mutations in genes encoding three functional groups (HMTs, SWI/SNF chromatin remodeling complex, and the PI3K/AKT/mTOR pathway) in aggressive variants ranged between that of PTCs from TCGA data and PDTCs and ATCs from MSKCC data. Here, AKT1 is linked to Ehlers-Danlos syndrome, musculocontractural type.