A recent study assessing the role of N-cadherins in patients with invasive BLCA who had undergone radical cystectomy found N-cadherin expression to be observed in 43.7% of the patients significantly associating with advanced pathological stage, lymph node metastasis, and worse recurrence free survival [32]. The gene discussed is CDH2; the disease is metastatic malignant neoplasm in the lymph nodes.