Figure 2A shows Western blots and their analysis of the LPA receptors 1–5, which reveal the presence of LPA receptors 1, 2 and 4 in healthy and sickle RBCs, with receptor 4 being significantly increased in SCD RBCs. The immunocytochemistry data and their statistical analysis in Figure 2B clearly support the results of the Western blot. The full gel Western blots for all conditions are provided in Supplemental Figure S1. This evidence concerns the gene LPAR1 and Schnyder corneal dystrophy.