Figure 8A reveals a suppression of LPA-induced Ca2+ entry by the pharmacological interventions in wild-type RBCs, while in TRPC6−/− RBCs, Ca2+ entry is completely abolished. In human RBCs, Ca2+ entry upon incubation with the blocking agents (Figure 8B) is qualitatively the same as in wild-type mouse RBCs (Figure 8A). In RBCs of SCD patients, the Ca2+ response to LPA upon incubation with WTM and U0126 is upscaled compared to healthy donors (Figure 8B). The gene discussed is TRPC6; the disease is Schnyder corneal dystrophy.