We integrated four expression profiles, including 87 IPF samples and 40 normal samples and successfully found 11 key candidate genes (ANXA3, STX11, THBS2, MMP1, MMP9, MMP7, MMP10, SPP1, COL1A1, ITGB8, IGF1) related to the pathogenesis of IPF. This evidence concerns the gene COL1A1 and idiopathic pulmonary fibrosis.