They screened out 10 core genes (VCAM1, CDH1, CXCL12, JUN, CTGF, SERPINE1, CXCL1, EDN1, COL1A2, and SPARC) through bioinformatics analysis from the datasets GSE2052 and GSE35145, providing a theoretical basis for exploring the novel therapeutic targets for IPF diagnosis and treatment. Here, SERPINE1 is linked to idiopathic pulmonary fibrosis.