PDK1 and colonic neoplasm: In a study done by Pate et al. the investigators found that by using genetically engineered human colon cancer cell lines that overactive Wnt/β-catenin signaling drives aerobic glycolysis and lactic acid production by upregulating the genes pyruvate dehydrogenase kinase 1 (PDK1) and monocarboxylate transporter 1 (MCT1/SLC16A1) [58,61].