AMER1 and malignant colon neoplasm: However, in various cancers (i.e., colon cancer) mutations in the destruction complex components (e.g., APC, AXIN2 and FAM123B/WTX) or regulators of the receptors/ligand (e.g., RNF43/ZNRF3, RSPO2, or RSPO3) components can lead to unchecked Wnt signaling.