PPT-treated cells downregulated 397 genes that were associated with KEGG pathways linked to the same groups of p53 signaling, cell cycle, and metabolisms as E2 treatment, and additional PPAR signaling pathway, Fanconi anemia pathway, complement and coagulation cascades, primary bile acid biosynthesis, and butanoate metabolism (Figure 2C; Table 2; Supplemental Table S3). The gene discussed is TP53; the disease is Fanconi anemia.