TP53 and urinary bladder cancer: The suppressed pathways by DPN treatment were the same steroid hormone biosynthesis, cell cycle, and p53 signaling pathway as E2 and PPT; with additional pathways in human T-cell leukemia virus type 1 (HTLV-I) infection, bladder cancer, homologous recombination, and Fanconi anemia pathway, as well as DNA replication, base excision repair, nucleotide excision repair, and mismatch repair (Figure 2E; Table 2; Supplemental Table S5).