Here we present a large-scale next-generation sequencing (NGS) study of the CDR3 region of the TCR β-chain repertoire in a cohort of HGBL-DH/TH, while including a comparative analysis with a previously reported cohort of DLBCL showing no aberrations in BCL2, BCL6 and MYC (tnDLBCL) [10]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.