HMGB1 and adenocarcinoma: In Kaplan–Meier curves and Log-Rank tests with median concentrations of HMGB1 in the respective subgroup and at the respective time points as cutoff values, a significant stratification between high and low concentrations was found only in adenocarcinomas when median HMGB1 concentrations before therapy (p = 0.038) or before cycle 2 (p = 0.025) were applied.