As described above, upregulation of some components of the NLRP3 inflammasome, including increase of the NLRP3 protein, caspase 1 activity, and IL1β gene expression, is observed in rd10 retinas on postnatal Day 23 [28], and in other murine and canine models of RP (see Section 2). The gene discussed is IL1B; the disease is retinitis pigmentosa 1.