Feng et al. [60] proposed a new method, which extracts features from both the spatial and the temporal dimensions by performing three-dimensional convolution operations and when compared to other methods this method achieved a sensitivity of 82.98 ± 6.23, a specificity of 91.45 ± 6.75 and an accuracy of 90.18 ± 6.62 in PCa detection using contrast enhanced ultrasonography (CEUS), anti-PSMA (prostate specific membrane antigen) and the non-targeted blank agent as contrast agents. This evidence concerns the gene FOLH1 and posterior cortical atrophy.