XPA and de Sanctis-Cacchione syndrome: Herein, we identified (NM_000380.3: c.619C>T, p.Arg207*) mutation in exon 5 in three unrelated pedigrees; this mutation was previously identified in one Palestinian patient who had severe skin symptoms and De Sanctis-Cacchione syndrome, and one Brazilian XP patient who had severe photosensitivity but intermediate onset of neurological symptoms although the patient had complete absence of XPA protein [39,58].