Recent work by Rotinen et al. [80] has identified the ONECUT2 (OC2) transcription factor as a targetable master regulator of lethal PCa that is also associated with the development of neuroendocrine differentiation (NED) in CRPC, as OC2 functions as a survival factor that promotes metastasis, regulates AR, and activates genes promoting neuronal differentiation in mCRPC [80]. Here, ONECUT2 is linked to posterior cortical atrophy.