The development and progression of PCa are frequently associated with epigenetic changes such as global DNA hypomethylation, and the hypermethylation of genes such as GSTP1 (glutathione S-transferase Pi 1) and HOXD8, and the dysregulation of ncRNAs such as miR-129a (decreased expression) and miR-18a (increased expression) [231]. This evidence concerns the gene GSTP1 and posterior cortical atrophy.