Recent mechanistic insights revealed that HOXD-AS1 recruits WD repeat-containing protein 5 (WDR5), a key subunit of the lysine-specific methyltransferase 2A (MLL1) chromatin remodeling complex, and regulates target gene transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) to promote chemo-resistance of human prostate cancer cells [230]. Here, WDR5 is linked to prostate carcinoma.