ERG and adenocarcinoma: Evidence supporting the transdifferentiation of CRPC includes the similar frequency of transmembrane protease serine 2-v ets erythroblastosis virus E26 oncogene homolog (TMPRSS-ERG) translocations in adenocarcinoma and t-NEPC [75], and the concordance of TMPRSS-ERG translocation status in the foci of both tumor types in mixed adenocarcinoma and t-NEPC [76], as well as the significant overlap in the somatic copy number alterations between CRPC and t-NEPC [77,78].