The present study was carried out to investigate whether lycopene can ameliorate inflammatory responses (IL-6 expression, zymogen activation) by reducing oxidative stress (intracellular and mitochondrial ROS, NADPH oxidase activity, NF-κB activation, mitochondrial dysfunction) in EtOH/POA-stimulated pancreatic acinar cells, which are an in vitro model of alcoholic pancreatitis. Here, NFKB1 is linked to alcoholic pancreatitis.