Liu et al. demonstrated that the expression of IRS-1, isocitrate dehydrogenase 2 (IDH2), and glucose-6-phosphate 1-dehydrogenase 2 (G6PD2) were downregulated, and the suppressor of cytokine signaling 3 (SOCS3) expression was upregulated in db/db mice due to insulin resistance [14]. This evidence concerns the gene SOCS3 and Insulin resistance.