Strong familiarity and syndromic familial history were characteristic only for the families of pathogenic BRCA1/2 variant carriers, while families of probands carrying only the BRCA2 C-terminal stop codon did not differ from BRCA1/2 wild type patients’ families regarding HBOC syndrome-related tumor types (breast, ovarian, prostate and pancreatic cancer) (Table 2). This evidence concerns the gene BRCA2 and neoplasm.