IL6 and Parkinson disease: The direct involvement of mitochondria in AD and PD is confirmed by the compartmentalized ROS suppression mediating mitoTEMPO, where the treatment reduced the expression of pro-inflammatory mediators, IL−1, IL−6, TNF, iNOS, and COX-2 in murine microglia cells, limiting the nuclear translocation of NF-kB and MAPKs [215].