Mutations in human Trib2 are associated with increased levels of C/EBP in undifferentiated cancers like T-cell acute lymphoblastic leukemia (T-ALL) [10,14,85,86,87], hence it is unsurprising that trbl mutations have been uncovered in screens for regulators of tumor formation in Drosophila. This evidence concerns the gene TRIB2 and acute lymphoblastic leukemia.