It was demonstrated that miRNA-19a caused drug resistance by increasing Bcl-2 and MDR1 in MM cells in response to chemotherapy, and this process is controlled by the phosphatase and tensin homolog deleted on chromosome 10/phosphatidylinositol 3 kinase/Protein Kinase B (PTEN/AKT/pAKT)-signaling pathway [63]. This evidence concerns the gene AKT1 and Miyoshi myopathy.