The mechanistic evaluations established that the increase of Snail1 production in BTZ-resistant MM cells directly augmented transcription of the intracellular multidrug resistance gene 1 (MDR1) and reduced P53 protein production via the Snail1/hsa-miRNA-22-3p/P53 pathway to decrease programmed cell death. Here, SNAI1 is linked to Miyoshi myopathy.