Moreover, PHF19 stimulates the phosphorylation of EZH2 (enhancer of zeste homolog 2; the catalytic subunit of PRC2) via phosphoinositide-dependent kinase 1/protein kinase B (PDK1/AKT) signaling, and its increased expression was demonstrated also in MM [54]. The gene discussed is AKT1; the disease is Miyoshi myopathy.