To better reproduce the TME architecture, Totti et al. developed a porous polyurethane scaffold coated with fibronectin, one of the main components of the extracellular matrix, and they showed that this system enhanced long-term tumor proliferation and collagen-I production compared to uncoated scaffolds, as well as induced a spatial oxygen and nutrient gradient [42]. The gene discussed is FN1; the disease is neoplasm.