Lithium, a well-known downregulator of GSK3β, which is the main inhibitor of the WNT/β-catenin pathway, was proposed to reverse the overactivity of GSK3 in BD, which is linked to a proinflammatory status, abnormally enhanced oxidative stress, the reduction of neurotrophic factors, and enhanced apoptosis [76,77]. Here, GSK3B is linked to Behcet disease.