Large (e.g., >100 kb), rare CNVs (i.e., observed in <1% of the population) have been consistently associated with schizophrenia (e.g., OR = 1.15) [13,14,15]; and have yielded important insights into the genetic etiology schizophrenia, CNV loci associated with schizophrenia, include deletions at the 22q11.2, 2p16.3 (NRXN1), 3q29, 15q11.2, and 15q13.3 loci, duplications at the 16p11.2 and 7q11.23 loci, and deletions or duplications at the 1q21.1 and 7p36.3 (VIPR2) loci [16,17,18]. This evidence concerns the gene NRXN1 and schizophrenia.