We observed a significant induction in the levels of C3, CP enzyme, growth factor IGFBP4, and cytokine CXCL10 and interferon signaling-related genes including (IFNβ, ISG15, MX2 and OASL2), some of which have been recognized for their role either in obesity or inflammation. The gene discussed is IGFBP4; the disease is obesity due to melanocortin 4 receptor deficiency.