We observed a significant induction in the levels of C3, CP enzyme, growth factor IGFBP4, and cytokine CXCL10 and interferon signaling-related genes including (IFNβ, ISG15, MX2 and OASL2), some of which have been recognized for their role either in obesity or inflammation. This evidence concerns the gene ISG15 and obesity due to melanocortin 4 receptor deficiency.