It can down-regulate the pro-inflammatory mediators, such as the intercellular adhesion molecule-1 (ICAM-1), cyclo-oxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) for controlling diabetes and preventing obesity via reduction of the total amount of cholesterol and triglyceride contents in plasma and liver [34,35,36,37]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.