Taking together all the different strategies to identify new candidate genes for SPS germline predisposition, including searching for potentially disruptive germline variants and germinal-tumor comparison, the final most promising candidate genes identified were ANXA10, ASXL1, CFTR, DOT1L, HIC1, INO80, KLF3, MCM3AP, MCM8, PDLIM2, POLD1, TP53BP1, WNK2 and WRN (Table 2). Here, WRN is linked to neoplasm.