DOT1L and neoplasm: Taking together all the different strategies to identify new candidate genes for SPS germline predisposition, including searching for potentially disruptive germline variants and germinal-tumor comparison, the final most promising candidate genes identified were ANXA10, ASXL1, CFTR, DOT1L, HIC1, INO80, KLF3, MCM3AP, MCM8, PDLIM2, POLD1, TP53BP1, WNK2 and WRN (Table 2).