Finally, using more stringent filtering criteria based on compatible biological functions as epigenetic regulators, senescence and the previous involvement in cancer development, 12 candidate genes with potentially pathogenic genetic variants were selected, including ANXA10, ASXL1, CFTR, DOT1L, INO80, KLF3, MCM3AP, MCM8, POLD1, TP53BP1, WNK2 and WRN. No relevant copy number variants (CNV) were identified, therefore, only single-nucleotide variants (SNV) and insertion/deletion variants (indels) were considered for variant prioritization. The gene discussed is POLD1; the disease is cancer.