In conclusion, we suggest 14 new candidate genes to be involved in the germline predisposition to SPS (ANXA10, ASXL1, CFTR, DOT1L, HIC1, INO80, KLF3, MCM3AP, MCM8, PDLIM2, POLD1, TP53BP1, WNK2 and WRN) involved in senescence, epigenetics regulation or cancer. The gene discussed is DOT1L; the disease is cancer.