In conclusion, we suggest 14 new candidate genes to be involved in the germline predisposition to SPS (ANXA10, ASXL1, CFTR, DOT1L, HIC1, INO80, KLF3, MCM3AP, MCM8, PDLIM2, POLD1, TP53BP1, WNK2 and WRN) involved in senescence, epigenetics regulation or cancer. This evidence concerns the gene WNK2 and cancer.