Noteworthy, hMENA/hMENAΔv6 overexpression defines a CAF subtype with pro-tumoral functions and hMENA expression in CAFs is able to regulate both autocrine and paracrine TGFβ signaling, leading to the regulation of TGFβ-mediated crosstalk between CAFs and tumor cells (unpublished data). This evidence concerns the gene TGFB1 and neoplasm.