TGFβ inhibits the expression of the epithelial splicing factor epithelial splicing regulatory proteins 1/2 (ESRP1/2) and primes the switching of hMENA isoforms by excluding the exon 11a in mammary epithelial and breast cancer cells [33,34,188,189,190]. The gene discussed is TGFB1; the disease is breast carcinoma.