CASP1 and malaria: Yu and colleagues [199] showed that inflammasomes may have antimalaria immunity role, by negatively regulating IFN-I cytokines signaling, which may partly explain why mice with deficiency in different inflammasome genes (AIM2−/−, NLRP3−/−, CASP-1−/−, and IL1R−/−) were resistant to lethal P. yoelii infection and severe malaria outcomes.