Investigations in P. chabaudi-infected mice and P. vivax symptomatic malaria human patients revealed the high expression of the pyroptotic genes CASP-1 and IL-1β in splenic macrophages and DCs, as well as in peripheral blood monocytes, as a result of ASC-dependent NLRP3/NLRP12 inflammasome assembly, which contributes to pyrogenic cytokines release and strong inflammation, a characteristic of malaria [48]. The gene discussed is NLRP12; the disease is malaria.