Furthermore, they shed light on CASP-8’s complementary role in activating pyrogenic cytokines, such as IL-1β and TNF-α, and cleavage of GSMD, considering that the animals with combined deficiencies of CASP-8/1/11 or CASP-8/GSDM-D presented better life expectancy and were resistant to CM pathogenesis [197]. This evidence concerns the gene CASP8 and cutaneous mastocytosis.