TGFB1 and neoplasm: This deregulation of the inflammatory response is widely associated with immune system evasion by inhibiting the expression of tumor antigens and, therefore, inducing immune tolerance through the secretion of suppressive molecules, such as IL-10, TGF-β and prostaglandin E2, and the expression of inhibitory checkpoint molecules, such as PD-L1 and CTLA-4, and tumor-derived chemokines [149].