ANK1 and histiocytic sarcoma: Hereditary spherocytosis (HS) is a relatively common hereditary hemolytic anemia caused by defects in the cellular membrane of RBCs [111] The majority of defects occur in five different genes encoding red blood cell membrane proteins: SPTA1 (alpha-spectrin), SPTB (beta-spectrin), ANK1 (Ankyrin 1), SLC4A1 (Band 3 or solute Carrier Family 4) and EPB42 (Erythrocytic Protein 4.2) [112,113].