Thus, emerging evidence reveals that the LOX and LOXL family are involved in various diseases related to pathogenic tissue fibrosis, including idiopathic pulmonary fibrosis (IPF), renal fibrosis, cardiac fibrosis, hepatic fibrosis and systemic sclerosis [14,15,16,17,18]. This evidence concerns the gene LOXL3 and idiopathic pulmonary fibrosis.