Given the limited number of reports demonstrating the relationship between hypertrophic and keloid scar-tissue formation and corresponding ECM remodeling, including activity by both catabolic and anabolic enzymes, we compared the gene-expression levels of MMPs, LOX, and LOXLs, which regulate ECM degradation and collagen cross-linking with various tissue origins [13], among NHK scar tissues. The gene discussed is LOX; the disease is keloid.