T2DM induces activation of several cytokines, such as TNF-α, interleukin-6 (IL-6), interleukin 1-beta (IL-1β), growth factor-beta (TGF-β), which together lead to vascular endothelium and myocardial inflammation, cardiomyocyte hypertrophy, change in cell metabolism, cardiomyocyte death, fibroblasts activation and fibrosis, generating diabetic cardiomyopathy [54]. The gene discussed is IL1B; the disease is diabetic cardiomyopathy.