GLUT4 is the only one of its family that is not located in the cell membrane remaining in the vesicles into the cells, and it is necessary to activate PI3K pathway in order to facilitate AKT signaling to translocate the vesicle until the membrane to capture glucose [23,24], and its disturbance can contribute to the development of T2DM. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.