However, the high-risk group has more dysregulated immune system-related pathways such as Allograft rejection, Graft-versus-host disease, Inflammatory bowel disease, Intestinal immune network for IgA production, Rheumatoid arthritis, Staphylococcus aureus infection (Figure 3C,D), which are downregulated pathways in LUAD high-risk group (Figure S18). This evidence concerns the gene CD79A and inflammatory bowel disease.