Pathway enrichment of DEGs at active subnetworks shows that the genes playing role in active subnetworks are much more related to cancer pathways such as PI3K-Akt signaling pathway, Ras signaling pathway, Small-cell lung cancer, Breast cancer, Gastric cancer, Proteoglycans in cancer and Rap1 signaling pathway (Figure 4). This evidence concerns the gene AKT1 and small cell lung carcinoma.