The genes play role in metabolic pathways, cancer and immune system-related pathways such as Central carbon metabolism in cancer, Glycolysis, Cholesterol metabolism, Amino sugar and Nucleotide sugar metabolism, HIF-1 signaling pathway, TNF signaling pathway, IL-17 signaling pathway, Chemokine signaling pathway and Wnt signaling pathway (Table S2). This evidence concerns the gene TNF and cancer.