LUSC gene expression signature including 33 genes of which ALDH7A1 [68], ALK [69], EDN1 [70], FABP6 [71], HKDC1 [72], IGSF1 [73], KBTBD11 [74], NOS1 [75], SLC9A9 [76], STK24 [77], UBB [78], ZNF703 [79] have been shown with oncogenic relations while RGMA [80] is candidate tumor suppressors. The gene discussed is IGSF1; the disease is neoplasm.