However, the high-risk group has more upregulated metabolic pathways such as Central carbon metabolism in cancer, Protein digestion and absorption, Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Cysteine and methionine metabolism, Glutathione metabolism, Ribosome biogenesis in eukaryotes; and downregulated immune-related pathways such as JAK-STAT signaling pathway, TNF signaling pathway, Primary immunodeficiency, T cell receptor signaling pathway distinctly from low-risk group (Figure S19). The gene discussed is TNF; the disease is inborn error of immunity.