They play role in mostly in metabolic pathways, cancer and immunity related pathways such as Arginine and proline metabolism, Glycolysis/Gluconeogenesis, HIF-1 signaling pathway, Non-small-cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer and TGF-beta signaling pathway (Table S4). The gene discussed is CD274; the disease is non-small cell lung carcinoma.