LUSC risk groups have mostly similar cancer-related active pathways, however only low-risk group has Nucleotide excision repair, Adherens junction and Alpha-Linolenic acid metabolism pathways, while high-risk group has cancer and metabolism-related pathways such as Basal cell carcinoma, Prolactin signaling pathway, Apoptosis, Mitophagy, Choline metabolism in cancer, Insulin signaling pathway, Carbohydrate digestion and absorption, Central carbon metabolism in cancer with immune system-related Measles and Influenza A pathways. This evidence concerns the gene INS and cancer.