LUSC low-risk group has downregulated PI3K-Akt signaling pathway, Phenylalanine metabolism, Tyrosine metabolism, Phospholipase D signaling pathway, Proteoglycans in cancer and Tight junction pathways with upregulated Hippo signaling pathway and Small-cell lung cancer distinctly from high-risk group (Figure S19). The gene discussed is PIK3CA; the disease is small cell lung carcinoma.