TP53 and cancer: Risk groups of LUSC have common dysregulated pathways (Figure 5C,D), which are highly related to cancer, such as Cell cycle, DNA replication, Base excision repair, p53 signaling pathway which are upregulated at both risk groups (Figure S19), on the other hand, they also share ECM–receptor interaction, Cell adhesion molecules, Focal adhesion pathways with immune system-related pathways such as Chemokine signaling pathway, Complement and coagulation cascades, Cytokine–cytokine receptor interaction, which are downregulated at both risk groups (Figure S19).