PGF and fetal growth restriction: In women developing preeclampsia (PE) or/and intrauterine growth restriction (IUGR), angiogenic factor placental growth factor (PlGF), and anti-angiogenic factor soluble fms-like tyrosine kinase (sFlt-1), and its relation, are a clinically useful tool for the prediction, prognosis, and management of these complications [15,16].