Besides, it has also been reported that daily administration of GYY4137 for 4 weeks can significantly reduce the degree of myocardial fibrosis and systolic blood pressure in spontaneously hypertensive rats by decreasing the total collagen contents of myocardium, α-smooth muscle actin levels, and oxidative stress through the deactivation of the transforming growth factor beta (TGF-β)/Smad2 pathway [151]. The gene discussed is TGFB1; the disease is Myocardial fibrosis.