TGFB1 and Myocardial fibrosis: Further reports show that H2S can attenuate matrix deposition and myocardial fibrosis in diabetic rats and improve the matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) status through the inhibition of TGF-β-mediated collagen accumulation together with Janus kinase (JAK) 1/2-signal transducer and activator of transcription (STAT) 1/3/5/6 and wingless and Int-1 (Wnt) signaling cascades, thereby resulting in a subsequent decrease in type I and type III collagen and CF [152,153].