As previously described, germ-line heterozygous mutations in the TP53 or TP63 gene are the molecular basis of the specific P53- and P63-related genetic disorders; then, it is conceivable that in the cells of affected patients, being P53 and P63 tetrameric TFs, wild-type, mixed, and mutant tetramers are formed. This evidence concerns the gene TP53 and hereditary disease.