TIE1 and melanoma: Pre-treatment of mice with AB-Tie1-39 but not IgG controls before intravenous (i.v.)injection of B16F10 melanoma cells reduces the number of metastatic lung lesions suggesting that Tie1 blockade prevents tumor cell lodging to the endothelium; this was confirmed on AB-Tie1-39 treated HUVEC cells in vitro.