I.v. injection of TNFα conjugated to the angiogenic vessel-homing peptide ‘CNGRCG’ (NGR-TNF) reduces lung metastases in an adjuvant treatment regimen in mice bearing spontaneous breast cancer metastatic to lung, and in experimental melanoma metastases, demonstrating that blood vessels in metastatic lesions are sufficiently altered for targeted therapy [63]. This evidence concerns the gene TNF and melanoma.