In conjunction with our previously published studies indicating absolute requirements for Ig BCR [17], C’3 [51,52], IL4 [53] and IFNγ/IFNR [54] in the development of the SS disease in our SSS mice, our transcriptome analyses presented here suggest the third scenario described above is the central bioprocess occurring in the salivary glands at around 4 months of age. This evidence concerns the gene IFNAR2 and synovial sarcoma.