Both Trp53 R172H and loss of Trp53 triggered multiple new oncogenic mutations (Supplementary Table S1) well-known for their role in CRC, including protein-modifying mutations in Arid1a, Arid1b, Atm, Kmt2a/b/d (Mll1/2/4), Cdh1, Cdk4/6, Erbb2 and Jak3, which are among the most frequent oncogenic mutations in human CRC. Here, CDK4 is linked to colorectal carcinoma.