Hence, a chimeric peptide hybrid consisting of melittin fused via a GGGGS linker to the pro-apoptotic peptide d(KLAKLAK)2 (i.e., GIGAVLKVLTTGLPALISWIKRKRQQGGGGS-d[KLAKLAKKLAKLAK]) efficiently induced the selective mitochondrial-mediated apoptotic cell death of M2 macrophages in vitro and (CD206+) M2-like tumor-associated macrophages in vivo, reducing tumor growth rates, tumor mass and angiogenesis [53]. Here, MRC1 is linked to neoplasm.