Van den Hoogenhof et al., compared 18 DCM patients carrying RBM20 alterations to 22 DCM patients carrying TTN alterations, and found that 44% of patients carrying any RBM20 alteration had sustained ventricular arrhythmias (Sustained VT or VF) when compared to 5% of patients carrying any TTN alteration, despite similar LVEF. This evidence concerns the gene TTN and familial dilated cardiomyopathy.