Similarly, several studies have demonstrated that irisin plays a developmental role in regulating the process of neuronal differentiation and maturation [152], induces the expression of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) [147,152], and could exert neuroprotective effects on neurodegenerative diseases, improving memory impairment and synaptic plasticity [152]. Here, BDNF is linked to neurodegenerative disease.