AGT and cardiac hypertrophy: Accordingly, irisin has been shown to protect cardiomyocytes against apoptosis and dysfunction induced by different stressful stimuli, such as lipotoxicity [107], H2O2 [108], hypoxia-reoxygenation [109,110], and doxorubicin-induced oxidative stress [111], as well as alleviating angiotensin-II-induced cardiac hypertrophy and fibrosis [15,112,113] and pressure overload-induced cardiac hypertrophy [114].