Each standard deviation (SD ≈ 4.4 μmol/L) increment in bilirubin levels predicted by rs6431625 in the UGT1A1 gene was not associated with risk of pancreatic cancer (OR per one-standard deviation, 1-SD 1.02; 95% of confidence interval (CI) 0.95–1.11), whereas higher bilirubin levels predicted by non-UGT1A1 SNPs showed an inverse association with pancreatic cancer overall (OR 0.74; 95% CI 0.61–0.89), with similar risk estimates among men and women (OR 0.75; 95% CI 0.58–0.96, and OR 0.73; 95% CI 0.55–0.97, per 1-SD increment, respectively) (Figure 1A). This evidence concerns the gene UGT1A1 and familial pancreatic carcinoma.