Here, we describe two unrelated families with autosomal dominant pathogenic variants in EPHA2, which segregate with bilateral congenital cataracts and microphthalmia: a four-generation family with missense mutation c.1751C>T, p.(Pro584Leu) identified using whole genome sequencing (WGS) (Figure 1, Table 1), and a two-generation family with splice site variant c.2826-9G>A identified through panel-based next-generation sequencing (NGS) (Figure 2, Table 2). The gene discussed is EPHA2; the disease is early-onset non-syndromic cataract.