In this study, we identified through next-generation sequencing (NGS) autosomal dominant EPHA2 variants segregating congenital cataracts and bilateral microphthalmia in two unrelated families: (i) missense variant c.1751C>T, p.(Pro584Leu) and (ii) splicing variant c.2826-9G>A. Here, EPHA2 is linked to early-onset non-syndromic cataract.