In contrast, for H5N1, the combined-route and aerosol-exposed animals showed similar transient decreases in lymphocyte, T-cell, B-cell, and NK-cell numbers, acute monocyte activation, and increased Ki67 expression on CD8 T-cells, but not CD4 T-cells, on day 7–10 after infection (Figure 6). The gene discussed is MKI67; the disease is infection.