On the other hand, using a microarray with more than 50,000 genetic variants, Zúñiga et al. [57] found that RPAIN (Replication protein-A-interacting protein) gene, also known as hRIP (human Rev-interacting protein), located in chromosome 17p13, is associated with influenza A H1N1 virus infection severity in a Mexican mestizo population. Here, RPAIN is linked to swine influenza.