Hyperglycemia led to a significant increase in the level of TF (p < 0.01), PAI-1 (p < 0.001), H2O2 (p < 0.01), and MDA (p < 0.01), and a significant decrease in the level of t-PA (p < 0.01) and NO2/NO3 (p < 0.01) and the expression level of eNOS (p < 0.01). The gene discussed is SERPINE1; the disease is Hyperglycemia.