SERPINE1 and Hyperglycemia: In conclusion, the mechanism of reduced arterial thrombosis in adrenalectomized STZ-induced diabetic rats could be related to reduced plasma ALDO level, which is well known as a prothrombotic factor [7,8,9,10], and to reduced blood glucose level, as hyperglycemia has been shown to be a potent inducer of PAI-1 expression [58].