MGMT and glioblastoma: In a randomized phase III clinical trial (NCT00045968), the addition of DCVax to regular therapy (Tmz) in newly diagnosed GBM patients prolonged the two and three-year survival rate by 66.7% and 46.4% respectively in patients with methylated MGMT, whereas in patients with unmethylated MGMT, the two and three-year survival rate is 32.1% and 11% respectively [189].