Inhibited cell proliferation. Alteration in mitochondrial membrane potential (MMP), neutralization of lysosomal pH Increased ratio of LC3-II/I and p26 in cell indicating Inhibition of autophagic influx mediated by cathepsin B and mainly ROS. Co-treatment of SB365 and Tmz exerted an additive effect. Suppression of tumor growth in xenograft model [356]. This evidence concerns the gene CTSB and neoplasm.