Cholecalciferol administration seems to ameliorate albuminuria in CKD patients, even if the data in literature are not conclusive: Molina et al. [19] treated 101 non-dialysis CKD patients with 666 IU/day oral cholecalciferol, with urinary albumin-to-creatinine ratio (uACR) decreasing from 284 (189–425) to 167 mg/g (105–266) at 6 months (geometric mean with 95% CI, p < 0.001). The gene discussed is ALB; the disease is chronic kidney disease.